nPEP Toolkit to Prevent HIV Infection

The nPEP Toolkit to Prevent HIV Infection is a new Alive! Maryland resource that highlights key elements of Non-Occupational Post-Exposure Prophylaxis (nPEP) management. PEP is effective in preventing HIV infection when administered rapidly—ideally within 2 hours and no later than 72 hours—after an exposure. 

The toolkit contains: 

• Risk assessments 
• nPEP at-a-glance checklist
• Steps for evaluation of need
• Treatment and follow-up
• Billing codes
• Payment assistance information
• Maryland nPEP resources 

This toolkit aims to achieve the following goals: 

• Reinforce that HIV exposure is an emergency that requires rapid response, with immediate administration of the first dose of PEP medications. 
• Reduce the under- and over-prescribing of PEP by describing the benefits of PEP and providing guidance for identifying high-risk HIV exposures for which PEP is indicated.
• Ensure prescription of PEP regimens are effective and well-tolerated. 
• Assist clinicians in recognizing and addressing challenges to successful completion of a PEP regimen.
• Detail the baseline testing, monitoring, and follow-up that should accompany prescription of a 28-day course of PEP.